Recent Advances in the Generation of Nitrilium Betaine 1,3-Dipoles

Abstract Nitrilium betaine 1,3-dipoles are ubiquitous reagents in organic chemistry, with applications ranging from natural product synthesis to materials science. Given the high reactivity of these zwitterionic motifs, they invariably generated situ a suitable precursor, prior use. This short review summarises recent progress development modern approaches towards formation 1,3-dipoles, and their within diverse range fields. 1 Introduction 2 Nitrile Ylides 2.1 2H-Azirine Rearrangement 2.2 Addition Nitriles Carbenes 3 Imines 3.1 2,5-Tetrazole Thermolysis 3.2 Photolysis 3.3 Diaryl Sydnone 4 Oxides 4.1 Hypervalent Iodine 4.2 The Nitroso Radical 4.3 Green Chemistry Approaches 4.4 Other 5 Conclusions